2001

In-universe

 * Unknown date
 * The movie  II: Trouble on the Hubble, starring Pauly Shore, is released.
 * 's ex-girlfriend Michelle leaves her husband and behind and freezes herself for 265  years  (later changed to 990 by Lars),  unaware that Fry has also been frozen.
 * Brain spawn use the Infosphere to start a thousand-year quest to obtain all knowledge in.

Real-world

 * 21 January
 * Episode thirty-four, "Parasites Lost", is aired on FOX.
 * 24 January
 * Comic Two, "...But Deliver Us to Evil!", is released.
 * 4 February
 * Episode thirty-three, "Amazon Women in the Mood", is aired on FOX.
 * 11 February
 * Episode thirty-eight, "Bendless Love", is aired on FOX.
 * 18 February
 * Episode thirty-nine, "The Day the Earth Stood Stupid", is aired on FOX.
 * 25 February
 * Episode fourty, "That's Lobstertainment!", is aired on FOX.
 * 4 March
 * Episode thirty-seven, "The Birdbot of Ice-Catraz", is aired on FOX.
 * 11 March
 * Episode thirty-six, "The Luck of the Fryrish", is aired on FOX.
 * 28 March
 * Comic three, "The Owner of Mars Attacks!", is released.
 * 1 April
 * Episode fourty-one, "The Cyber House Rules", is aired on FOX.
 * 8 April
 * Episode fourty-three, "Insane in the Mainframe", is aired on FOX.
 * 22 April
 * Episode fourty-five, "Bendin' in the Wind", is aired on FOX.
 * 6 May
 * Episode fourty-six, "Time Keeps on Slippin'", is aired on FOX.
 * 13 May
 * Episode fourty-seven, "I Dated a Robot", is aired on FOX.
 * 23 May
 * Comic four, "DOOP the Right Thing!", is released.
 * 25 July
 * Comic five, "Who's Dying to Be a Gazillionaire?", is released.
 * 24 October
 * Comic six, "Xmas Time Is Fear", is released.
 * 9 December
 * Episode fifty-one, "Roswell that Ends Well", is aired on FOX.
 * 23 December
 * Episode thirty-five, "A Tale of Two Santas", is aired on FOX.