Parasites Lost

Act I: She's got more meat than a cow!
The Planet Express Ship pulls over for a fuel stop. Lighting his cigar while refuelling on ethanol and tonic, Bender blows himself. Meanwhile, in the men's room, Fry buys an egg-salad sandwich. While eating the sandwich, Fry makes several comments about how terrible it tastes, ("It's like there's a party in my mouth and everyone is throwing up), but also says that he has had worse. While Fry finishes his sandwich, Leela starts to clean the windshield of the Planet Express Ship, removing, among other things, the Voyager Probe.  Several truckers (including Sal) make derogatory, sexist comments toward Leela as she cleans the ship, and Fry attempts to defend her, but only ends up insulting her further.

Back at the Planet Express building Fry despairs over being unable to please Leela. This despair is interrupted when he and Bender go to fix the plasma-fusion boiler, which Scruffy is unable to fix due to a "schedule conflict". However, since they are unqualified to make such repairs, the boiler explodes, lodging a lead pipe in Fry's abdomen. During an examination from Dr. Zoidberg, who claims that it is normal for your lead pipe to hurt, the pipe is cut in half mysteriously, and the holes in Fry's abdomen seal themselves. Dr. Zoidberg gives Fry a more thorough examination, which the rest of the crew watches behind a 2-way mirror and on a video screen, while eating popcorn. Hermes eats his popcorn using a Jai Alai scoop, because Fry has been eating all the silverware. During Fry's colonoscopy, it is revealed that there is a colony of parasitic worms living in Fry's bowels, within a city made of the silverware Fry ate. The Professor reveals that the only way to get rid of the parasites is to enter Fry using a microscopic version of the Planet Express Ship. After learning of their journey, Bender calls shotgun, to the disappointment of Dr. Zoidberg.

Act II: Nobody make a smell!
The Professor creates micro-droids for each crew member, which, apparently, are cheaper than shrinking them. The micro-droids are controlled via net suits.

The Professor lays out the plan, which involves entering through Fry's ear, and travelling through his systems until they reach the pelvic splanchnic ganglion. Irritation of the ganglion will expel the parasites, among other things, from Fry. The force of the expulsion, according to the Professor, will make Fry lucky to still have his bones afterwards. Fry cannot be warned of the plan, however, as the worms know everything he knows. Leela distracts Fry long enough to launch the miniature Planet Express ship into his ear. In order to keep him distracted, Leela proposes taking a walk.

The Planet Express Crew discovers that the worms are actually making Fry smarter, stronger, and more coordinated. As they were navigating through the nasal passage, Fry sniffed a rose, which he gave to Leela. This bombarded the Planet Express Ship with pollen, prompting Zoidberg to suggest they escape through a nasal capillary. This surprises everyone, as it's the first time he's expressed any correct knowledge of human anatomy. He reveals, however, that he learned it from a decongestant commercial.

The nasal capillary takes the crew into the heart, or "love muscle", as the Professor calls it. Dr. Zoidberg's usual lack of knowledge of human anatomy returns as he mentions that the heart is where food is digested. The crew will be safe as long as nothing causes Fry's heart to beat faster, according to the Professor. Unbeknown to the crew, Fry is stepping into a puddle to help Leela avoid getting her feet wet. Upon taking his hand, his heart starts to beat faster, causing Bender to panic. Professor Farnsworth sets a course for a cholesterol-encrusted valve, in an attempt to avoid certain doom.

After leaving the heart, the ship passes a group of worms jazzercising Fry's muscles, making him as strong and flexible as Gumbercules. Outside of Fry's body, while on their walk, Leela sees Sal, and suggests they cross the street and blend in with a group of pimps. Fry confronts Sal, demanding an apology. Leela protests, saying that he is "bulging with what could be muscles." Fry tears off his shirt, revealing his newfound strength. After a short confrontation, being disarmed and defeated, Sal apologizes to Leela.

Act III: Worms to battle stations!
The Planet Express Ship sets off a proximity alarm as they neared the stomach, and several worm sentry ships converge and open fire on the Planet Express Ship. After taking a couple hits from the worm fighters, Bender tries to abandon ship through the emergency exit, but is restrained by Hermes and Zoidberg. Ahead, the entrance to the stomach is starting to close, and barely make it through, thanks to the help of the worm fighters. They arrive in the bowel and begin an assault on the worm city.

At a coffee-shop across the street from Planet Express, Fry finally shares his feelings with Leela, which he was previously not able to articulate. Leela realizes that the worms may have something to do with the new Fry, and runs off to the Planet Express building.

Just before reaching the ganglion, Zoidberg enters the room, revealing that, although Fry was sterilized by the professor's F-Ray (1ACV13), the worms were able to repair the damage. Leela scans herself to create a micro-droid for herself, and enters Fry by shooting herself into his cup of coffee. Before the others can stimulate the ganglion, Leela arrives and destroys her micro-droid co-workers with a fire axe.

Act IV: Ever wonder what makes special sauce so special?
After destroying the microscopic versions of the crew, Leela takes off her net-suit and tells the Professor that Fry might be better off with the worms. Fry enters the room and demands an explanation.

After receiving his explanation, Fry says that the worms are the best parasites he's ever had. Later, Leela takes Fry to her apartment, where pulls out a holophonor, one of the most difficult instruments in the universe. He plays, and the hologram shows Fry and Leela in a variety of forms, dancing across the universe. Without saying a word, Leela takes fry into the bedroom, where says she loves what Fry has become. Fry realizes she may not love him for who he truly is, but instead, for what the worms have made him into. He returns to the Planet Express building and makes a micro-droid of himself, which he drops into the back of his pants.

Inside his own bowel, Fry confronts the Lord Mayor of Col&oacute;n. Fry explains his situation and asks the worms to leave, but the Lord Mayor refuses, citing that he came in on the sandwich and raised a cloud of spores in Fry's bowel. Fry and the Lord Mayor engage in a sword fight, which takes them to Fry's brain. Fry threatens to injure himself to evict the worms. They call his bluff, but he cuts several connections within his brain, including the hand-eye coordination lobe. The Lord Mayor explains that he has only damaged his brain to the extent of a week of binge drinking or 5 minutes of cell phone use. He reaches the medulla oblongata, and threatens to kill himself if they do not leave. After a brief standoff, the worms agree to leave, but give him a promise that they will find their way back--"Ever wonder what makes special sauce so special? Yo."

Act V: I'm still seduced from before.
Fry returns to Leela's apartment. He asks to play the holophonor, but Leela protests, saying that she was still seduced from earlier. He insists and starts playing, creating a Frankenstein-like monster. Leela asks what it was supposed to mean, to which Fry responds 'I don't know. I got nervous and started thinking about neck bolts." Leela realizes he's become an idiot again.  Fry asks for a chance to prove that it was him, not the worms that made her love him.  Fry pulls out a baggie of massage oil and offers to give him the massage he used to give Amy.  Leela, covering herself, shoves the holophonor in his face and tells him to leave.

Later that night, Fry begins his first lesson on the holophonor, creating a rudimentary hologram of Leela.

Trivia

 * Opening scene is shown to be on Historic Route 66 (expressed mathmatically).
 * Fuel available at Greasy Sue's Greasy Truck Stop is Light Matter, Dark Matter, Wassa Matter, Ethanol and Ethanol & Tonic.
 * Sign in mens room reads "All Employees Must Wipe Hands on Pants"
 * Alien graffiti on the construction site reads: WATCH FOR FALLING HUMANS
 * Leela's apartment is a spoof of the old Maxell commercials, which featured a similar setting.
 * Although Fry was sterilized in Fry and the Slurm Factory by the F-Ray, the worms seem to have repaired this functionality, as evidenced by Zoidberg's riding a sperm, and Fry's impregnating his own grandmother in Roswell that Ends Well.
 * These areas of Fry's body are listed on the elevator:
 * Brain
 * Lungs
 * Liver
 * Ball Room
 * Door Close
 * This episode is named #4 on IGN's list of Top 25 Futurama Episodes.

Quotes
Zoidberg: Yippeekayaye! You'll never guess where I've been! (Comes in riding ones of Fry's sperm, see paragraph above indicating that he had been to Fry's testicles)
 * Leela: You're not gonna eat a sandwich from a truck stop men's room are you? Fry: What's the worst thing that can happen... ewww, it's like a party in my mouth and everyone is throwing up.
 * Zoidberg: Ahh, the hypochondriac's back, so what is it this time? Fry: Well, my lead pipe hurts a little. Zoidberg: That's normal, next patient!
 * Bender: Yo old guy, why do we have to use those tiny micro droids? Can't you just shrink us? Professor: Oh my no, that would require extremely tiny atoms, have priced those lately? I'm not made of money! Leave me alone!

Continuity

 * Fry mentions his massage he gave to Amy when he was going out with her.
 * Fry plays the holophonor again with the help of another outside force.
 * Fry plays the holophonor again with the help of another outside force.
 * Fry plays the holophonor again with the help of another outside force.

Characters

 * Amy
 * Bender
 * Hermes
 * Leela
 * Fry
 * Professor Farnsworth
 * Sal
 * Zoidberg
 * Scruffy

Episode Credits

 * Writer
 * Eric Kaplan
 * Director
 * Peter Avanzino
 * Voice Actors
 * Billy West
 * Katey Sagal
 * John DiMaggio
 * Phil LaMarr
 * DVD Commentary
 * Peter Avanzino
 * Rich Moore
 * Eric Kaplan
 * David X. Cohen
 * Scott Vanzo
 * Matt Groening