War between the Nibblonians and the brain spawn

The war between the Nibblonians and the Brain Spawn was an immense conflict which began milliseconds after the Big Bang when the Brain Spawn were created. Their only goal was to learn all knowledge of the universe before destroying it, they apparently killed several species, or at least the Dinosaurs. By 1999, the Brain Spawn built an immense center of knowledge, the Infosphere. The Nibblonians freeze the only people who can save the universe.

In 3002 the Brain Spawn invaded Earth and made every human stupid with the exception of Fry who stopped the invasion, and the Nibblonians ate the last brains.

Later, in 3004, the Brain Spawn had nearly finished acquiring the knowledge of universe, but Nibbler sent Fry to active the Quantum Interphase Bomb which propels the Infosphere and all Brain Spawn to a parallel universe where it's impossible to return to our universe.