War between the Nibblonians and the brain spawn

The war between the Nibblonians and the Brain Spawn was an immense conflict who begins milseconds after the Big Bang when the Brain Spawn were created. Their only goal was to learn all knowledge of the universe before destroy it, they apparently killed several species, or at least the Dinosaurs. By 1999, the Brain Spawn builded an immense center of knowledge, the Infosphere. The Nibblonians freeze the only people who can save the universe.

In 3002 the Brain Spawn invaded Earth and make every humans stupid with the exception of Fry who stopped the invasion, and the Nibblonians ate the last brains.

Later, in 3004 the Brain Spawn had nearly finished to stock all the knowledge of universe, but Nibbler use Fry to active the Quantum Interphase Bomb which propulses the Infosphere and all Brain Spawn to a parallel universe where it's impossible to return to our universe.